Research

White Papers

 
dreamstime_xxl_98501191+144dpi.jpg
 

  1. What are Chromosome Conformations?

    Learn more about the science behind chromosome conformations.

    Willem Westra PhD, Ewan Hunter PhD, Alexandre Akoulitchev PhD, Oxford BioDynamics Plc

  2. What is EpiSwitch™ and how is it used?

    A background on EpiSwitch™ and its applications in precision medicine.

    Willem Westra PhD, Ewan Hunter PhD, Alexandre Akoulitchev PhD, Oxford BioDynamics Plc

  3. EpiSwitch™ Biomarker Discovery Process

    From discovery to validation

    Willem Westra PhD, Ewan Hunter PhD, Alexandre Akoulitchev PhD, Oxford BioDynamics Plc

  4. How are EpiSwitch™ markers detected?

    How EpiSwitch™ detection methodology exceeds the highest industry standards for PCR-based readouts.

    Francis Grand PhD, Willem Westra PhD, Alexandre Akoulitchev PhD, Oxford BioDynamics Plc

  5. EpiSwitch™ Methodology and application case studies

    A robust and reliable methodology for personalised medicine

    Aroul Ramadass PhD, Matthew Salter BSc, Ewan Hunter PhD, Willem Westra PhD, Alexandre Akoulitchev PhD

 
 

Landmark Studies & Useful Reviews

 
holos_recent publications.jpg
 

  1. The Prospective Study of Epigenetic Regulatory Profiles in Sport and Exercise Monitored Through Chromosome Conformation Signatures

    Hall E.C.R., Murgatroyd C., Stebbings G.K., Cunniffe B., Harle L., Salter M., et al Genes. 2020 Aug 7;11(8):905.

  2. The Genome Conformation As an Integrator of Multi-Omic Data: The Example of Damage Spreading in Cancer.

    Tordini, F., Aldinucci, M., Milanesi, L. & Merelli, I. Front. Genet. 7, (2016).

  3. Epigenetic chromatin conformation changes in peripheral blood can detect thyroid cancer.

    Yan, H. et al. Surgery (2018). doi:10.1016/J.SURG.2018.05.081

  4. Chromosome conformation signatures define predictive markers of inadequate response to methotrexate in early rheumatoid arthritis.

    Carini, C. et al. J. Transl. Med. 16, 1–11 (2018).

  5. Initial Identification of a Blood-Based Chromosome Conformation Signature for Aiding in the Diagnosis of Amyotrophic Lateral Sclerosis.

    Salter, M. et al. EBioMedicine 33, 169–184 (2018)

  6. The Chromosomal Conformation Signature: A New Kid on the Block in ALS Biomarker Research?

    Poesen K. EBioMedicine. 2018;33:6-7.

  7. Epigenetic footprints for neurodegenerative and autoimmune conditions: a comparative analysis

    E.Hunter, A. Ramadass, H. Womersley, A. Akoulitchev

  8. Epigenetic regulation of gene expression: Emerging applications for horses.

    Dindot, S. V. & Cohen, N. D. J. Equine Vet. Sci. 33, 288–294 (2013).

  9. Epigenetics and aging. (2010).

    Mellor, J.

  10. Epigenetic Biomarkers for Parkinson’s Disease: From Diagnostics to Therapeutics.

    Jakubowski, J. L. & Labrie, V. J. Parkinsons. Dis. 7, 1–12 (2017).

  11. A glimpse into the epigenetic landscape of gene regulation.

    Mellor, J., Dudek, P. & Clynes, D. Curr. Opin. Genet. Dev. 18, 116–122 (2008).

 
 

Recent Publications in Epigenetics

 
holos_recent publications.jpg